"PreventionGenetics, part of Exact Sciences"[submitter] AND "LEP"[gene - ClinVar - NCBI

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Items: 17

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 358815	NM_000230.3(LEP):c.21C>T (p.Cys7=)	LEP	Single nucleotide variant (synonymous variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 2635971	NM_000230.3(LEP):c.22G>A (p.Gly8Arg)	LEP (G8R)	Single nucleotide variant (missense variant)	LEP-related condition	GUncertain significance
Select item 1422020	NM_000230.3(LEP):c.30G>C (p.Leu10Phe)	LEP (L10F)	Single nucleotide variant (missense variant)	LEP-related condition +1 more	GUncertain significance
Select item 910456	NM_000230.3(LEP):c.53A>G (p.Tyr18Cys)	LEP (Y18C)	Single nucleotide variant (missense variant)	Obesity due to congenital leptin deficiency +2 more	GConflicting classifications of pathogenicity
Select item 3042985	NM_000230.3(LEP):c.132C>T (p.Asp44=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition	GLikely benign
Select item 3052124	NM_000230.3(LEP):c.133A>G (p.Ile45Val)	LEP (I45V)	Single nucleotide variant (missense variant)	LEP-related condition	GUncertain significance
Select item 3047910	NM_000230.3(LEP):c.174C>G (p.Thr58=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition	GLikely benign
Select item 3044720	NM_000230.3(LEP):c.204C>G (p.Pro68=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition	GLikely benign
Select item 435745	NM_000230.3(LEP):c.276A>G (p.Arg92=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition +1 more	GLikely benign
Select item 2136611	NM_000230.3(LEP):c.328G>A (p.Val110Met)	LEP (V110M)	Single nucleotide variant (missense variant)	LEP-related condition +1 more	GUncertain significance
Select item 2634563	NM_000230.3(LEP):c.367A>G (p.Ser123Gly)	LEP (S123G)	Single nucleotide variant (missense variant)	LEP-related condition	GUncertain significance
Select item 2893938	NM_000230.3(LEP):c.372C>T (p.Gly124=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition +1 more	GLikely benign
Select item 3050910	NM_000230.3(LEP):c.375G>A (p.Leu125=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition	GLikely benign
Select item 2132136	NM_000230.3(LEP):c.429G>A (p.Glu143=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition +1 more	GLikely benign
Select item 2172424	NM_000230.3(LEP):c.492C>T (p.Ser164=)	LEP	Single nucleotide variant (synonymous variant)	LEP-related condition +1 more	GBenign/Likely benign
Select item 1210010	NM_000230.3(LEP):c.496G>C (p.Gly166Arg)	LEP (G166R)	Single nucleotide variant (missense variant)	LEP-related condition	GUncertain significance
Select item 3031515	NM_000230.3(LEP):c.*4C>T	LEP	Single nucleotide variant (3 prime UTR variant)	LEP-related condition	GLikely benign